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Article

Metal-dependent inhibition of HIV-1 integrase by beta-diketo acids and resistance of the soluble double-mutant (F185K/C280S).

Molecular pharmacology - 1 Sept 2003

Marchand Christophe, Johnson Allison A, Karki Rajeshri G, Pais Godwin C G, Zhang Xuechun, Cowansage Kiriana, Patel Tapan A, Nicklaus Marc C, Burke Terrence R, Pommier Yves

Abstract excerpt

The beta-diketo acids (DKAs) represent a major advance for anti-HIV-1 integrase drug development. We compared the inhibition of HIV-1 integrase by six DKA derivatives using the wild-type enzyme or the double-mutant F185K/C280S, which has been previously used for crystal structure determinations....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12920196
DOI: 10.1124/mol.64.3.600

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12920196-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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