Article
Proteasomal targeting of a viral oncogene abrogates oncogenic phenotype and enhances immunogenicity.
Blood - 15 Dec 2003
Tellam Judy, Connolly Geoff, Webb Natasha, Duraiswamy Jaikumar, Khanna Rajiv
Abstract excerpt
The ability of viral or mutated cellular oncogenes to initiate neoplastic events and their poor immunogenicity have considerably undermined their potential use as immunotherapeutic tools for the treatment of human cancers. Using an Epstein-Barr virus-encoded oncogene, latent membrane protein 1 (L...
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