Article
Convergent evolution of SIV env after independent inoculation of rhesus macaques with infectious proviral DNA.
Virology - 1 Aug 2003
Buckley Kathleen A, Li Pei-Lin, Khimani Anis H, Hofmann-Lehmann Regina, Liska Vladimir, Anderson Daniel C, McClure Harold M, Ruprecht Ruth M
Abstract excerpt
The env gene of three simian immunodeficiency virus (SIV) variants developed convergent mutations during disease progression in six rhesus macaques. The monkeys had been inoculated with supercoiled plasmids encoding infectious proviruses of SIVmac239 (a pathogenic, wild-type strain), SIVdelta3 (the live attenuated vaccine strain derived from SIVmac239), or SIVdelta3+ (a pathogenic progeny virus that had evolved...
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