Article
A long insertion reverts the functional effect of a substitution in acetylcholinesterase.
Protein engineering - 1 Jul 2003
Villatte F, Schulze H, Schmid R D, Bachmann T T
Abstract excerpt
Proteins are thought to undertake single substitutions, deletions and insertions to explore the fitness landscape. Nevertheless, the ways in which these different kind of mutations act together to alter a protein phenotype remain poorly described. We introduced incrementally the single substitution W290A and a 26 amino acid long insertion at the 297 location in the Nippostrongylus brasiliensis...
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