Article
Strong association of the Saitohin gene Q7 variant with progressive supranuclear palsy.
Neurology - 12 Aug 2003
de Silva R, Hope A, Pittman A, Weale M E, Morris H R, Wood N W, Lees A J
Abstract excerpt
Recent reports are inconclusive in showing that the Q7R polymorphism of the novel Saitohin gene, nested in intron 9 of the tau gene, is associated with AD. The authors show that this polymorphism is in complete linkage disequilibrium with the extended tau H1/H2 haplotype and that the Q variant and QQ genotype of Q7R are strongly associated with progressive supranuclear palsy, implicating it as a possibly...
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