Cloning, functional analysis and post-transcriptional regulation of a type II DNA topoisomerase from Leishmania infantum. A new potential target for anti-parasite drugs.

Abstract excerpt

We identified a type II topoisomerase enzyme from Leishmania infantum, a parasite protozoon causing disease in humans. This protein, named Li topo II, which displays a variable C-terminal end, is located in the kinetoplast. The cloned gene encoding Li-TOP2 compensates for the slow growth of topo...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Antiprotozoal Agents
• Share to DNA, Superhelical
• Share to DNA Topoisomerases, Type II