Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conditional knock-out of lipoic acid protein ligase 1 reveals redundancy pathway for lipoic acid metabolism in Plasmodium berghei malaria parasite.

Parasites & vectors - 27 Jun 2017

Wang Min, Wang Qiong, Gao Xiang, Su Zhong

Abstract excerpt

BACKGROUND: Lipoic acid is a cofactor for α-keto acid dehydrogenase system that is involved in the central energy metabolism. In the apicomplexan parasite, Plasmodium, lipoic acid protein ligase 1 (LplA1) and LplA2 catalyse the ligation of acquired lipoic acid to the dehydrogenase complexes in the mitochondrion. The enzymes LipB and LipA mediate lipoic acid synthesis and ligation to the enzymes in the apicoplast....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Knockout Techniques
Share to Ligases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipid Metabolism

Share to Mice, Inbred BALB C

Share to Organisms, Genetically Modified

Share to Plasmodium berghei

Share to Protozoan Proteins

Share to Tetracyclines

Source

Open in PubMed Open full text

Identifiers

PMID: 28655332
DOI: 10.1186/s13071-017-2253-y
PMCID: PMC5488443

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conditional knock-out of lipoic acid protein ligase 1 reveals redundancy pathway for lipoic acid metabolism in Plasmodium berghei malaria parasite.PMID 28655332Read ↗

Knockout studies reveal an important role of Plasmodium lipoic acid protein ligase A1 for asexual blood stage parasite survival.Semantic proximity Read ↗

A key role for lipoic acid synthesis duringPlasmodiumliver stage developmentSemantic proximity Read ↗

A toolbox for conditional control of gene expression in apicomplexan parasitesSemantic proximity Read ↗

Identification and Characterization of a Liver Stage-Specific Promoter Region of the Malaria Parasite PlasmodiumSemantic proximity Read ↗

A genetic screen in rodent malaria parasites identifies five new apicoplast putative membrane transporters, one of which is essential in human malaria parasitesSemantic proximity Read ↗

Some conditions apply: Systems for studying Plasmodium falciparum protein functionSemantic proximity Read ↗

A putative ATP/GTP binding protein affects Leishmania mexicana growth in insect vectors and vertebrate hostsSemantic proximity Read ↗

Development of an inducible protein expression system based on the protozoan host Leishmania tarentolaeSemantic proximity Read ↗

Functional analysis of an AMP forming acetyl CoA synthetase from Leishmania donovani by gene overexpression and targeted gene disruption approaches.Semantic proximity Read ↗

PfClpC Is An Essential Clp Chaperone Required For Plastid Integrity And Clp Protease Stability In <i>Plasmodium falciparum</i>Semantic proximity Read ↗

Fatty acid metabolism in the Plasmodium apicoplast: Drugs, doubts and knockoutsSemantic proximity Read ↗

Chemical Rescue of Malaria Parasites Lacking an Apicoplast Defines Organelle Function in Blood-Stage Plasmodium falciparumSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.