Article
Evidence for genetic linkage between the gene segments encoding NSP4 and VP6 proteins in common and reassortant human rotavirus strains.
Journal of clinical microbiology - 1 Aug 2003
Iturriza-Gòmara Miren, Anderton Emma, Kang Gagandeep, Gallimore Chris, Phillips Wendy, Desselberger Ulrich, Gray Jim
Abstract excerpt
NSP4-encoding genes of 78 human rotavirus strains of common or reassortant genotypes were characterized by reverse transcription-PCR followed by sequencing and phylogenetic analysis. It was found that all the human strains characterized clustered into only two of the five known NSP4 genotypes. Linkage between NSP4 genotypes and VP6 subgroups was 100%, NSP4 genotype A being linked to VP6 of subgroup I (SGI) and...
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