Article
Assignment of the group A rotavirus NSP4 gene into genotypes using a hemi-nested multiplex PCR assay: a rapid and reproducible assay for strain surveillance studies.
Journal of medical microbiology - 1 Mar 2009
Bányai Krisztián, Bogdán Ágnes, Szücs György, Arista Serenella, De Grazia Simona, Kang Gagandeep, Banerjee Indrani, Iturriza-Gómara Miren, Buonavoglia Canio, Martella Vito
Abstract excerpt
The rotavirus non-structural protein NSP4 has been implicated in a number of biological functions during the rotavirus cellular cycle and pathogenesis, and has been addressed as a target for vaccine development. The NSP4 gene has been classified into six genotypes (A-F). A semi-nested triplex PCR was developed for genotyping the major human NSP4 genotypes (A-C), which are common in human rotavirus strains but are...
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