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Article

Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kit

1 Aug 2003

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Share to Cytokine Signaling Pathways and Interactions
Share to Mast cells and histamine
Share to Phagocytosis and Immune Regulation

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 12901973
DOI: 10.1016/s0301-472x(03)00112-7

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Effects of tyrosine kinase inhibitor STI571 on human mast cells bearing wild-type or mutated c-kitPMID 12901973Read ↗

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Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies.Semantic proximity Read ↗

Constitutive activation of c-kit by the juxtamembrane but not the catalytic domain mutations is inhibited selectively by tyrosine kinase inhibitors STI571 and AG1296.Semantic proximity Read ↗

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Juxtamembrane mutant V560GKit is more sensitive to Imatinib (STI571) compared with wild-type c-kit whereas the kinase domain mutant D816VKit is resistant.Semantic proximity Read ↗

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