Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2-mutated fibroblasts.

The FEBS journal - 1 Feb 2009

Frangini Miriam, Rampazzo Chiara, Franzolin Elisa, Lara Mari-Carmen, Vilà Maya R, Martí Ramon, Bianchi Vera

Abstract excerpt

Mitochondrial thymidine kinase (TK2) catalyzes the phosphorylation of thymidine in mitochondria. Its function becomes essential for dTTP synthesis in noncycling cells, where cytosolic dTTP synthesis via R1/R2 ribonucleotide reductase and thymidine kinase 1 is turned down. Mutations in the nuclear gene for TK2 cause a fatal mtDNA depletion syndrome. Only selected cell types are affected, suggesting that the other...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytosol
Share to Mitochondrial Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Protein Subunits

Share to Ribonucleotide Reductases

Share to Thymidine

Share to Thymidine Kinase

Share to Thymidine Phosphorylase

Share to Thymine Nucleotides

Source

Identifiers

PMID: 19154348
DOI: 10.1111/j.1742-4658.2008.06853.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Unchanged thymidine triphosphate pools and thymidine metabolism in two lines of thymidine kinase 2-mutated fibroblasts.PMID 19154348Read ↗

Mitochondrial Thymidine Kinase and the Enzymatic Network Regulating Thymidine Triphosphate Pools in Cultured Human CellsSemantic proximity Read ↗

Mitochondrial deoxyribonucleoside triphosphate pools in thymidine kinase 2 deficiency.Semantic proximity Read ↗

Altered gene transcription profiles in fibroblasts harboring either TK2 or DGUOK mutations indicate compensatory mechanisms.Semantic proximity Read ↗

Thymidine kinase 2 enzyme kinetics elucidate the mechanism of thymidine-induced mitochondrial DNA depletion.Semantic proximity Read ↗

Deoxyribonucleoside kinases in mitochondrial DNA depletion.Semantic proximity Read ↗

Mammalian ribonucleotide reductase subunit p53R2 is required for mitochondrial DNA replication and DNA repair in quiescent cells.Semantic proximity Read ↗

Reversion of mtDNA depletion in a patient with TK2 deficiency.Semantic proximity Read ↗

Severe TK2 enzyme activity deficiency in patients with mild forms of myopathySemantic proximity Read ↗

Molecular insight into mitochondrial DNA depletion syndrome in two patients with novel mutations in the deoxyguanosine kinase and thymidine kinase 2 genes.Semantic proximity Read ↗

Selective muscle fiber loss and molecular compensation in mitochondrial myopathy due to TK2 deficiency.Semantic proximity Read ↗

Regulation by degradation, a cellular defense against deoxyribonucleotide pool imbalances.Semantic proximity Read ↗

Loss of thymidine kinase 2 alters neuronal bioenergetics and leads to neurodegeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.