A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin.

doi:10.1096/fj.02-1132com

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Article

A novel cellular marker of insulin resistance and early atherosclerosis in humans is related to impaired fat cell differentiation and low adiponectin.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Aug 2003

Jansson Per-Anders, Pellmé Fredrik, Hammarstedt Ann, Sandqvist Madeléne, Brekke Hilde, Caidahl Kenneth, Forsberg Margeta, Volkmann Reinhard, Carvalho Eugénia, Funahashi Tohru, Matsuzawa Yuji, Wiklund Olle, Yang Xiaolin, Taskinen Marja-Riita, Smith Ulf

Abstract excerpt

The epidemic increase in type 2 diabetes can be prevented only if markers of risk can be identified and used for early intervention. We examined the clinical phenotype of individuals characterized by normal or low IRS-1 protein expression in fat cells as well as the potential molecular mechanisms related to the adipose tissue. Twenty-five non-obese individuals with low or normal IRS-1 expression in subcutaneous...

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PMID: 12890697
DOI: 10.1096/fj.02-1132com

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