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Article

Short interfering RNA-mediated interference of gene expression and viral DNA accumulation in cultured plant cells

28 Jul 2003

Abstract excerpt

Gene silencing mediated by double-stranded RNA is a sequence-specific RNA degradation mechanism highly conserved in eukaryotes that serves as an antiviral defense pathway in both plants and Drosophila. Short interfering RNAs (siRNAs), the 21- to 23-nt double-stranded intermediates of this natural defense mechanism, are becoming powerful tools for reducing gene expression and countering viral infection in a...

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PMID: 12886005
DOI: 10.1073/pnas.1733874100

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