Article
Prostate-specific antitumor activity by probasin promoter-directed p202 expression.
Molecular carcinogenesis - 1 Jul 2003
Wen Yong, Giri Dipak, Yan Duen-Hwa, Spohn Bill, Zinner Ralph G, Xia Weiya, Thompson Timothy C, Matusik Robert J, Hung Mien-Chie
Abstract excerpt
p202, an interferon (IFN) inducible protein, arrests cell cycle at G1 phase leading to cell growth retardation. We previously showed that ectopic expression of p202 in human prostate cancer cells renders growth inhibition and suppression of transformation phenotype in vitro. In this report, we showed that prostate cancer cells with stable expression of p202 were less tumorigenic than the parental cells. The...
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