Production of teicoplanin by a mutant of Actinoplanes teicomyceticus.

Abstract excerpt

Teicoplanin, a glucopeptide antibiotic, was produced by a mutant of Actinoplanes teicomyceticus at 300 mg l-1 using mannose and yeast extract as carbon and nitrogen sources in flask culture and at 500 mg l-1 in 5-1 jar fermenter. Teicoplanin production was 25-fold higher than in the parent strain.

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