Article
Interleukin-3Ralpha+ myeloid dendritic cells and mast cells develop simultaneously from different bone marrow precursors in cultures with interleukin-3.
The Journal of investigative dermatology - 1 Aug 2003
Baumeister Thomas, Rössner Susanne, Pech Gabi, de Bruijn Marella F T R, Leenen Pieter J M, Schuler Gerold, Lutz Manfred B
Abstract excerpt
The distinct developmental routes of dendritic cells and mast cells from murine bone marrow cultures with interleukin-3 are unclear. We found that short-term bone marrow cultures with interleukin-3 after 8-10 d consist of about 10%-30% dendritic cells and 70%-90% mast cell precursors, and only after 4-6 wk do homogeneous populations of mast cells emerge. Phenotypical and functional analysis of...
Topics
- Animals
- Bone Marrow Cells
- Cell Differentiation
- Cell Movement
- Cells, Cultured
- Cellular Senescence
- Dendritic Cells
- Endocytosis
- Granulocyte-Macrophage Colony-Stimulating Factor
- Interleukin-12
- Interleukin-12 Subunit p40
- Interleukin-3