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Article

Interleukin-3Ralpha+ myeloid dendritic cells and mast cells develop simultaneously from different bone marrow precursors in cultures with interleukin-3.

The Journal of investigative dermatology - 1 Aug 2003

Baumeister Thomas, Rössner Susanne, Pech Gabi, de Bruijn Marella F T R, Leenen Pieter J M, Schuler Gerold, Lutz Manfred B

Abstract excerpt

The distinct developmental routes of dendritic cells and mast cells from murine bone marrow cultures with interleukin-3 are unclear. We found that short-term bone marrow cultures with interleukin-3 after 8-10 d consist of about 10%-30% dendritic cells and 70%-90% mast cell precursors, and only after 4-6 wk do homogeneous populations of mast cells emerge. Phenotypical and functional analysis of...

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Identifiers

PMID: 12880419
DOI: 10.1046/j.1523-1747.2003.12380.x

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