Identification of germline 185delAG <i>BRCA1</i> mutations in non‐Jewish Americans of Spanish ancestry from the San Luis Valley, Colorado

Abstract excerpt

BACKGROUND: Germline mutations in the BRCA1 and BRCA2 genes are associated with an inherited predisposition to breast and ovarian carcinoma, and specific mutations in these genes are found at increased frequency in certain populations. The authors observed a repeated occurrence of the 185delAG mutation (BRCA1; also known as 187delAG) in a non-Jewish population that originated from the San Luis Valley in Colorado....

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