Investigating the origin of the slow-binding inhibition of HCV NS3 serine protease by a novel substrate based inhibitor.

doi:10.1021/bi034661v

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Investigating the origin of the slow-binding inhibition of HCV NS3 serine protease by a novel substrate based inhibitor.

Biochemistry - 29 Jul 2003

Liu Yaya, Saldivar Ayda, Bess Joshua, Solomon Larry, Chen Chih-Ming, Tripathi Rakesh, Barrett Leo, Richardson Paul L, Molla Akhteruzzaman, Kohlbrenner William, Kati Warren

Abstract excerpt

Indandiones were identified as a novel class of small molecule inhibitors of hepatitis C virus NS3 serine protease from high throughput screening. We further studied the structure activity relationships and the mechanisms of inhibition for this class of compounds. Our studies revealed two similar...

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Investigating the origin of the slow-binding inhibition of HCV NS3 serine protease by a novel substrate based inhibitor.

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