Article
Founder mutation in the BRCA1 gene in Malay breast cancer patients from Singapore.
Human mutation - 1 Aug 2003
Lee Ann S G, Ho G H, Oh P C, Balram C, Ooi L L, Lim D T H, Wong C Y, Hong G S
Abstract excerpt
The mutation spectrum of the BRCA1 gene among ethnic groups from Asia has not been well studied. We investigated the frequency of mutations in the BRCA1 gene among Malay breast cancer patients from Singapore, independent of family history. By using the protein truncation test (PTT) and direct sequencing, BRCA1 mutations were detected in 6 of 49 (12.2%) unrelated patients. Four novel missense mutations in exon 11,...
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