Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

[Polymorphism at the glutathione S-transferase pi locus as a risk factor for ifosfamide nephrotoxicity in children].

Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego - 1 Apr 2003

Zielińska Elzbieta, Zubowska Małgorzata, Bodalski Jerzy

Abstract excerpt

The aim of the study was an assessment of various risk factors for nephrotoxicity of ifosfamide (IF) in children taking into account the importance of the concentrations of toxic metabolites of the drug excreted with urine and the polymorphism of genes encoding S-glutathione transferases of mi, pi, and theta classes (GSTM1, GSTP1 and GSTT1). The study was carried out in 37 children aged 2-17 years (mean age 8.9...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Deletion
Share to Glomerular Filtration Rate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glutathione S-Transferase pi

Share to Glutathione Transferase

Share to Immunosuppressive Agents

Share to Isoenzymes

Share to Kidney

Share to Magnetic Resonance Imaging

Source

Identifiers

PMID: 12868187

Genes

GSTP1
GSTM1
GSTT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

[Polymorphism at the glutathione S-transferase pi locus as a risk factor for ifosfamide nephrotoxicity in children].PMID 12868187Read ↗

Role of GSTM1, GSTP1, and GSTT1 gene polymorphism in ifosfamide metabolism affecting neurotoxicity and nephrotoxicity in children.Semantic proximity Read ↗

Analysis of CYP450 gene allelic variants can predict ifosfamide toxicity in Mexican paediatric patients.Semantic proximity Read ↗

Growth retardation and osteomalacia as a result of ifosfamide nephrotoxicity in a 3-year-old boy whose genotype reveals the genes encoding glutathione S-transferases GSTM1 and GSTT1.Semantic proximity Read ↗

[Transferase S-glutathione class pi gene (GSTP1) polymorphism in thyroid cancer patients].Semantic proximity Read ↗

[Impact of single nucleotide polymorphisms in glutathione S transferase gene GSTP1 in the treatment with oxaliplatin based chemotherapy].Semantic proximity Read ↗

[Frequency of gene polymorphic variants (phase II) of biotransformation of GSTT1 and GSTM1 xenobiotics among long-livers (Precarpathian region)].Semantic proximity Read ↗

Possible role of CYP2B6 genetic polymorphisms in ifosfamide-induced encephalopathy: report of three cases.Semantic proximity Read ↗

Hydroxylation and N-Dechloroethylation of Ifosfamide and Deuterated Ifosfamide by the Human Cytochrome P450s and Their Commonly Occurring PolymorphismsSemantic proximity Read ↗

Role of CYP2B6 and CYP3A4 in the In Vitro N-Dechloroethylation of (R)- and (S)-Ifosfamide in Human Liver MicrosomesSemantic proximity Read ↗

Activity of allelic variants of Pi class human glutathione S-transferase toward chlorambucil.Semantic proximity Read ↗

Ifosfamide, Fanconi's syndrome, and rickets.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.