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Article

Alpha-galactosylceramide (KRN7000) suppression of chemical- and oncogene-dependent carcinogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 5 Aug 2003

Hayakawa Yoshihiro, Rovero Stefania, Forni Guido, Smyth Mark J

Abstract excerpt

Recent studies have revealed significant efficacy of the marine sponge glycolipid, alpha-galactosylceramide (alpha-GalCer), in treatment of experimental metastatic cancers, infections, and autoimmune diseases. However, the capacity of alpha-GalCer to prevent tumor development had never, to our knowledge, been evaluated in mouse models of chemical- and oncogene-dependent carcinogenesis. In this study, we...

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Identifiers

PMID: 12867593
DOI: 10.1073/pnas.1630663100
PMCID: PMC170941

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