Article
The Arabidopsis AtLIG4 gene is required for the repair of DNA damage, but not for the integration of Agrobacterium T-DNA.
Nucleic acids research - 15 Jul 2003
van Attikum Haico, Bundock Paul, Overmeer René M, Lee Lan-Ying, Gelvin Stanton B, Hooykaas Paul J J
Abstract excerpt
The joining of breaks in the chromosomal DNA backbone by ligases in processes of replication, recombination and repair plays a crucial role in the maintenance of genomic stability. Four ATP-dependent ligases, designated DNA ligases I-IV, have been identified in higher eukaryotes, and each one has distinct functions. In mammals and yeast, DNA ligase IV is exclusively involved in the repair of DNA double-strand...
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