Article
Convergent pathobiologic model of Parkinson's disease.
Annals of the New York Academy of Sciences - 1 Jun 2003
Maguire-Zeiss Kathleen A, Federoff Howard J
Abstract excerpt
The etiology of Parkinson's disease (PD) has yet to be delineated. Human genetic studies as well as neurotoxicant and transgenic animal models of PD suggest that multiple events trigger the initiation of this progressive age-related neurodegenerative disorder. In addition, we propose that despite disparate disease triggers a convergent pathobiologic pathway exists leading to cell death. The common pathway model...
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