Article
[Bcl-2 in potentials precursors of nodular paragranuloma and its dedifferentiated variant (large cell B-lymphoma)].
Verhandlungen der Deutschen Gesellschaft fur Pathologie - 1 Jan 1992
Lorenzen J, Hansmann M L, Shibata D, Hell K, Klöckner A, Pezzella F, Fischer R
Abstract excerpt
We have investigated seven cases of large cell lymphomas (LCL) developing simultaneously or metachronously to nodular lymphocyte-predominant Hodgkin's disease (nodular paragranuloma, NP) for the presence of EBV and the chromosomal translocation t(14;18) by use of the polymerase chain reaction (PCR). The expression of the bcl-2 oncogene product in these cases and in five cases of progressive transformation of...
Topics
- Adult
- Aged
- Antigens, Neoplasm
- Antigens, Viral
- Chromosomes, Human, Pair 14
- Chromosomes, Human, Pair 18
- DNA-Binding Proteins
- Epstein-Barr Virus Nuclear Antigens
- Female
- GTP-Binding Proteins