The incorporation of an ion channel gene mutation associated with the long QT syndrome (Q9E-hMiRP1) in a plasmid vector for site-specific arrhythmia gene therapy: in vitro and in vivo feasibility studies.

doi:10.1089/104303403765701196

Article

The incorporation of an ion channel gene mutation associated with the long QT syndrome (Q9E-hMiRP1) in a plasmid vector for site-specific arrhythmia gene therapy: in vitro and in vivo feasibility studies.

Human gene therapy - 10 Jun 2003

Burton Denise Y, Song Cunxian, Fishbein Ilia, Hazelwood Senator, Li Quanyi, DeFelice Suzanne, Connolly Jeanne M, Perlstein Itay, Coulter Douglas A, Levy Robert J

Abstract excerpt

The present studies investigated the cardiac potassium channel missense mutation, Q9E-hMiRP1, for potential use as a gene therapy construct for cardiac arrhythmias. This gene abnormality is one of a number of mutations that can cause the long QT syndrome (LQTS), a hereditary arrhythmia disorder that is associated with sudden death. However, individuals who carry the Q9E-hMiRP1 variant are predisposed to...

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