Article
Trypanothione synthetase locus in Trypanosoma cruzi CL Brener strain shows an extensive allelic divergence.
Acta tropica - 1 Jul 2003
Tran Anh Nhi, Andersson Björn, Pettersson Ulf, Aslund Lena
Abstract excerpt
The protozoan parasite Trypanosoma cruzi, agent of Chagas' disease, displays an extensive genetic heterogeneity among strains and isolates. It is, therefore, important to determine the degree of polymorphism in potential candidates for drug design. Our studies on the organisation of the locus containing the gene encoding trypanothione synthetase (TcTRS) (an enzyme involved in the unique trypanothione pathway and...
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