Article
Synthesis of solution-phase combinatorial library of 4,6-diamino-1,2-dihydro-1,3,5-triazine and identification of new leads against A16V+S108T mutant dihydrofolate reductase of Plasmodium falciparum.
Bioorganic & medicinal chemistry - 17 Jan 2003
Vilaivan Tirayut, Saesaengseerung Neungruthai, Jarprung Deanpen, Kamchonwongpaisan Sumalee, Sirawaraporn Worachart, Yuthavong Yongyuth
Abstract excerpt
An efficient method to synthesize solution-phase combinatorial library of 1-aryl-4,6-diamino-1,2-dihydro-1,3,5-triazine was developed. The strategy involved an acid-catalyzed cyclocondensation between arylbiguanide hydrochlorides and carbonyl compounds in the presence of triethyl orthoacetate as...
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