Article
Two sets of HLA Class II DRB and DQB1 alleles co-segregate among family members in a single maternal haplotype.
Tissue antigens - 1 Jun 2003
Crowley J, Hagan R, Clancy D, Rooney G, Dunne C, Lawlor E, Hayden P, Little A-M, Soteriou B, Marsh S G E, Madrigal J A
Abstract excerpt
HLA class II typing by sequence specific oligonucleotide probes (SSOP) on the family of a Burkit's Lymphoma patient produced hybridization patterns indicating the presence of two DRB1, and two linked DQB1 genes on the same maternal chromosome. DRB and DQB1 exon 2 amplification products associated with the novel maternal haplotype were identified by DNA typing techniques: These products corresponded to DRB1*0101,...
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