Article
Association between leptin receptor gene polymorphisms and early-onset prostate cancer.
BJU international - 1 Jul 2003
Kote-Jarai Z, Singh R, Durocher F, Easton D, Edwards S M, Ardern-Jones A, Dearnaley D P, Houlston R, Kirby R, Eeles R
Abstract excerpt
OBJECTIVE: To report a case-control study examining the relationship between polymorphisms in the leptin receptor (OBR) gene and the development of young-onset prostate cancer, because epidemiological studies report that prostate cancer risk is associated with animal fat intake, and thus we investigated if this association occurs via this genetic mechanism. PATIENTS, SUBJECTS AND METHODS: The Lys109Arg (OBR1) and...
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