Article
Multiple Endocrine Neoplasia type 1.
European journal of internal medicine - 1 Mar 2008
Piecha Grzegorz, Chudek Jerzy, Wiecek Andrzej
Abstract excerpt
The co-occurrence of parathyroid hyperplasia with pancreatic endocrine tumours and/or pituitary adenoma is classified as Multiple Endocrine Neoplasia type 1 (MEN-1) and is caused by a germ-line mutation in MEN-1 gene encoding a tumour suppressor protein, menin. This review presents clinical expressions, diagnosis and management of the MEN-1 syndrome. Properties and mechanisms of menin functions are also reviewed.
Topics
- Gastrinoma
- Gene Expression
- Humans
- Hyperparathyroidism
- Insulinoma
- Multiple Endocrine Neoplasia Type 1
- Mutation
- Prolactinoma
- Proto-Oncogene Proteins