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Article

Quantitative trait loci for hypercalciuria in a rat model of kidney stone disease.

Journal of the American Society of Nephrology : JASN - 1 Jul 2003

Hoopes Richard R, Reid Robert, Sen Saunak, Szpirer Claude, Dixon Peter, Pannett Anna A J, Thakker Rajesh V, Bushinsky David A, Scheinman Steven J

Abstract excerpt

Hypercalciuria is the most common risk factor for kidney stones and has a recognized familial component. The genetic hypercalciuric stone-forming (GHS) rat is an animal model that closely resembles human idiopathic hypercalciuria, with excessive intestinal calcium absorption, increased bone resorption, and impaired renal calcium reabsorption; overexpression of the vitamin D receptor (VDR) in target tissues; and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Rats, Inbred F344

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Source

Identifiers

PMID: 12819244
DOI: 10.1097/01.asn.0000073920.43848.a3

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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