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Article

Tubulin polymerizing activity of dictyostatin-1, a polyketide of marine sponge origin

2 Jun 2003

Abstract excerpt

Dictyostatin-1 had previously been isolated from a marine sponge of the genus Spongia sp. and described as a cytotoxic agent to murine and human cancer cells, but its mechanism of activity was unknown. In a routine screening assay used to detect cytotoxic compounds of marine origin, dictyostatin-1 was identified as a highly active component in an extract from a Lithistida sponge and exploration into its...

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PMID: 12818367
DOI: 10.1016/s0006-2952(03)00192-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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