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Article

Molecular genetics of Alzheimer's disease: presenilin 1 gene analysis in a cohort of patients from the Poznań region.

Journal of applied genetics - 1 Jan 2003

Kowalska Anna, Wender Mieczyslaw, Florczak Jolanta, Pruchnik-Wolinska Danuta, Modestowicz Renata, Szczech Józef, Rossa Grzegorz, Kozubski Wojciech

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory loss and personality changes. Pathological hallmarks of AD are: deposition of amyloid plaques and neurofibrillary tangles in the brain, accompanied by neuronal and synaptic loss. The genetic background of AD is heterogeneous and strongly depends on the form of the disease. In most of the families with early-onset AD...

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PMID: 12817569

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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