Allelic amino acid substitutions affect the conformation and immunoreactivity of germ-cell alkaline phosphatase phenotypes.

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Article

Allelic amino acid substitutions affect the conformation and immunoreactivity of germ-cell alkaline phosphatase phenotypes.

Clinical chemistry - 1 Dec 1992

Hoylaerts M F, Manes T, Millán J L

Abstract excerpt

The gene encoding placental alkaline phosphatase (PLAP) displays a well-documented allelic polymorphism. Likewise, different phenotypes exist for the PLAP-related germ-cell alkaline phosphatase (GCAP). We investigated the extent to which various allelic GCAP positions are critical in determining...

Topics

Alkaline Phosphatase
Amino Acids
Antibodies, Monoclonal
Base Sequence
Binding Sites
Cloning, Molecular
Electrophoresis, Starch Gel
Enzyme Stability
Epitopes
Genotype
Germ Cells
Hot Temperature
Humans
Molecular Sequence Data
Mutagenesis, Site-Directed
Phenotype
Placenta
Polymorphism, Genetic

Source

Open in PubMed

Identifiers

PMID: 1281052

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-1281052-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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