Article
A mutant endonuclease IV of Escherichia coli loses the ability to repair lethal DNA damage induced by hydrogen peroxide but not that induced by methyl methanesulfonate.
Journal of bacteriology - 1 Dec 1992
Izumi T, Ishizaki K, Ikenaga M, Yonei S
Abstract excerpt
A mutant allele of the Escherichia coli nfo gene encoding endonuclease IV, nfo-186, was cloned into plasmid pUC18. When introduced into an E. coli xthA nfo mutant, the gene product of nfo-186 complemented the hypersensitivity of the mutant to methyl methanesulfonate (MMS) but not to hydrogen pero...
Topics
- Amino Acid Sequence
- Base Sequence
- DNA Damage
- DNA Repair
- DNA-(Apurinic or Apyrimidinic Site) Lyase
- Deoxyribonuclease IV (Phage T4-Induced)
- Endodeoxyribonucleases
- Enzyme Activation
- Escherichia coli
- Escherichia coli Proteins
- Hydrogen Peroxide
- Methyl Methanesulfonate
- Molecular Sequence Data
- Mutation