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Article

Tumor necrosis factor-alpha gene (TNF-alpha) -1031/-863, -857 single-nucleotide polymorphisms (SNPs) are associated with severe adult periodontitis in Japanese.

Journal of clinical periodontology - 1 Jun 2003

Soga Yoshihiko, Nishimura Fusanori, Ohyama Hideki, Maeda Hiroshi, Takashiba Shogo, Murayama Yoji

Abstract excerpt

OBJECTIVES: Tumour necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) participate in the establishment of inflammatory lesions in periodontitis. High production of these cytokines may relate to the severity of periodontitis. There have already been several studies examining the association between periodontitis and single nucleotide polymorphisms (SNPs) that affect cytokine productivity. Recently,...

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Identifiers

PMID: 12795791
DOI: 10.1034/j.1600-051x.2003.00287.x

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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