Article
Endocytosis of synaptotagmin 1 is mediated by a novel, tryptophan-containing motif.
Traffic (Copenhagen, Denmark) - 1 Jul 2003
Jarousse Nadine, Wilson Joshua D, Arac Demet, Rizo Josep, Kelly Regis B
Abstract excerpt
The rate at which a membrane protein is internalized from the plasma membrane can be regulated by revealing a latent internalization signal in response to an appropriate stimulus. Internalization of the synaptic vesicle membrane protein, synaptotagmin 1, is controlled by two distinct regions of its intracytoplasmic C2B domain, an internalization signal present in the 29 carboxyterminal (CT) amino acids and a...
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