Article
Complex interactions in Parkinson's disease: a two-phased approach.
Movement disorders : official journal of the Movement Disorder Society - 1 Jun 2003
Maraganore Demetrius M, de Andrade Mariza, Lesnick Timothy G, Farrer Matthew J, Bower James H, Hardy John A, Rocca Walter A
Abstract excerpt
The identification of pathogenic mutations in the three genes alpha-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 (UCHL1) has elucidated the ubiquitin proteasome system (UPS) and its potential role as a causal pathway in Parkinson's disease (PD). In addition, polymorphisms of the...
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