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Article

Neuroglian, Gliotactin, and the Na+/K+ ATPase are essential for septate junction function in Drosophila.

The Journal of cell biology - 9 Jun 2003

Genova Jennifer L, Fehon Richard G

Abstract excerpt

One essential function of epithelia is to form a barrier between the apical and basolateral surfaces of the epithelium. In vertebrate epithelia, the tight junction is the primary barrier to paracellular flow across epithelia, whereas in invertebrate epithelia, the septate junction (SJ) provides this function. In this study, we identify new proteins that are required for a functional paracellular barrier in...

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Identifiers

PMID: 12782686
DOI: 10.1083/jcb.200212054
PMCID: PMC2172966

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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Neuroglian, Gliotactin, and the Na+/K+ ATPase are essential for septate junction function in Drosophila.PMID 12782686Read ↗

Gliotactin, a novel marker of tricellular junctions, is necessary for septate junction development in Drosophila.Semantic proximity Read ↗

glaikit is essential for the formation of epithelial polarity and neuronal development.Semantic proximity Read ↗

Yurt, Coracle, Neurexin IV and the Na(+),K(+)-ATPase form a novel group of epithelial polarity proteins.Semantic proximity Read ↗

A conserved functional domain of Drosophila coracle is required for localization at the septate junction and has membrane-organizing activity.Semantic proximity Read ↗

The IgLON protein Lachesin is required for the blood-brain barrier in Drosophila.Semantic proximity Read ↗

The protein 4.1, ezrin, radixin, moesin (FERM) domain of Drosophila Coracle, a cytoplasmic component of the septate junction, provides functions essential for embryonic development and imaginal cell proliferation.Semantic proximity Read ↗

Septate junctions are required for ommatidial integrity and blood-eye barrier function in Drosophila.Semantic proximity Read ↗

Organizing a functional junctional complex requires specific domains of the Drosophila MAGUK Discs large.Semantic proximity Read ↗

Drosophila coracle, a member of the protein 4.1 superfamily, has essential structural functions in the septate junctions and developmental functions in embryonic and adult epithelial cells.Semantic proximity Read ↗

Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts.Semantic proximity Read ↗

A pump-independent function of the Na,K-ATPase is required for epithelial junction function and tracheal tube-size control.Semantic proximity Read ↗

Dynamic analysis identifies novel roles for DLG-1 subdomains in AJM-1 recruitment and LET-413-dependent apical focusing.Semantic proximity Read ↗

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