Article
Opsin activation as a cause of congenital night blindness.
Nature neuroscience - 1 Jul 2003
Jin Shengnan, Cornwall M Carter, Oprian Daniel D
Abstract excerpt
Three different mutations of rhodopsin are known to cause autosomal dominant congenital night blindness in humans. Although the mutations have been studied for 10 years, the molecular mechanism of the disease is still a subject of controversy. We show here, using a transgenic Xenopus laevis model, that the photoreceptor cell desensitization that is a hallmark of the disease results from persistent signaling by...
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