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Article

Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis.

Proceedings of the National Academy of Sciences of the United States of America - 10 Jun 2003

Yan Wei, Assadi Amir H, Wynshaw-Boris Anthony, Eichele Gregor, Matzuk Martin M, Clark Gary D

Abstract excerpt

Platelet-activating factor (PAF) has been shown to affect sperm motility and acrosomal function, thereby altering fertility. PAF acetylhydrolase 1b (PAFAH1B) hydrolyzes PAF and is composed of three subunits [the lissencephaly (LIS1) protein and alpha1 and alpha2 subunits] and structurally resembles a GTP-hydrolyzing protein. Besides the brain, transcripts for Lis1, alpha1, and alpha2 are localized to meiotic and...

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Identifiers

PMID: 12775763
DOI: 10.1073/pnas.1236145100
PMCID: PMC165851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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