Article
Over-representation of two specific haplotypes among chromosomes harbouring BRCA1 mutations.
European journal of human genetics : EJHG - 1 Jun 2003
Osorio Ana, de la Hoya Miguel, Rodríguez-López Raquel, Granizo Juan José, Díez Orland, Vega Ana, Durán Mercedes, Carracedo Angel, Baiget Montserrat, Caldés Trinidad, Benítez Javier
Abstract excerpt
The BRCA1 gene is included in a 200-400 kb region that is subjected to a recombination suppression mechanism; this region shows nearly complete linkage disequilibrium for a series of common biallelic polymorphisms, all of them with rarer allele frequency close to 0.4. These series of SNPs define two major haplotypes designated as class I and class II. In the present study, we have determined haplotype classes in...
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