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Varicella-Zoster Virus DNA in Cells Isolated from Human Trigeminal Ganglia

27 May 2003

Abstract excerpt

To determine the type of cell(s) that contain latent varicella-zoster virus (VZV) DNA, we prepared pure populations of neurons and satellite cells from trigeminal ganglia of 18 humans who had previously had a VZV infection. VZV DNA was present in 34 of 2,226 neurons (1.5%) and in none of 20,700 satellite cells. There was an average of 4.7 (range of 2 to 9) copies of VZV DNA per latently infected neuron. Latent...

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PMID: 12768016
DOI: 10.1128/jvi.77.12.6979-6987.2003

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