Article
FISH analyses for alterations in chromosomes 1, 2, 3, and 11 define high‐risk groups in neuroblastoma
16 May 2003
Abstract excerpt
BACKGROUND: The prognostic chromosomal markers 1p loss and MYCN amplification (MNA) are only present in a subgroup of approximately 30% of neuroblastomas. To further characterize high and low risk subsets we investigated alterations in chromosome arms 3p and 11q, additional changes in 1p and MYCN as well as the somy-status of chromosome 1 in the same sample. PROCEDURE: Fluorescence in situ hybridization (FISH)...
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