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Article

Subsenescent Telomere Lengths in Fibroblasts Immortalized by Limiting Amounts of Telomerase

1 Apr 2000

Abstract excerpt

Human fibroblasts expressing the catalytic component of human telomerase (hTERT) have been followed for 250-400 population doublings. As expected, telomerase activity declined in long term culture of stable transfectants. Surprisingly, however, clones with average telomere lengths several kilobases shorter than those of senescent parental cells continued to proliferate. Although the longest telomeres shortened,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 10744686
DOI: 10.1074/jbc.275.14.10072

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