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Article

The interaction between HIV-1 Gag and human lysyl-tRNA synthetase during viral assembly.

The Journal of biological chemistry - 25 Jul 2003

Javanbakht Hassan, Halwani Rabih, Cen Shan, Saadatmand Jenan, Musier-Forsyth Karin, Gottlinger Heinrich, Kleiman Lawrence

Abstract excerpt

Human lysyl-tRNA synthetase (LysRS) is a tRNA-binding protein that is selectively packaged into HIV-1 along with its cognate tRNALys isoacceptors. Evidence exists that Gag alone is sufficient for the incorporation of LysRS into virions. Herein, using both in vitro and in vivo methods, we begin to map regions in Gag and LysRS that are required for this interaction. In vitro reactions between wild-type and...

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PMID: 12756246
DOI: 10.1074/jbc.M301840200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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