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[A Japanese family with familial Alzheimer's disease associated with presenilin 1 mutation: relationship between younger age of onset and ApoE gene polymorphism].

No to shinkei = Brain and nerve - 1 Apr 2003

Marui Wami, Iseki Eizo, Sugiyama Naoya, Matsumura Takehiko, Suzuki Kyoko, Odawara Toshinari, Hino Hiroaki, Kosaka Kenji

Abstract excerpt

We previously reported a Japanese family with early-onset familial Alzheimer's disease associated with G 209 R presenilin 1(PS 1) mutation. There have been six patients across three generations in this family. In the present report, we described the clinical course, findings with neuroimaging and results of genetic examination of PS 1 and apolipoprotein E(ApoE) in three of six patients(II-1, III-1 and 2). The...

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PMID: 12755040

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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