Article
[Structural and functional changing induced by exposure to adaptive doses of X-rays in the human lymphocytes both normal and defective by reparation of DNA double strands breaks].
Radiatsionnaia biologiia, radioecologiia - 1 Jan 2000
Spitkovskiĭ D M, Veĭko N N, Ermakov A V, Kuz'mina I V, Makarenkov A S, Salimov A G, Terekhov S M, Karpukhin A V
Abstract excerpt
In the present work it is shown that the phenomenon of interphase chromosome centromeric region displacement, earlier revealed by the authors, is not realized in G0-lymphocytes with heterozygous BRCA1/2 gene mutations. The role of these genes in DNA double strand break (DSB) reparation is known. It is concluded that chromosome locus displacement is necessary for DSB repair, at least in the process of homologous...
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