Article
[Survivin mutants reverse the malignancy of HeLa cells].
Ai zheng = Aizheng = Chinese journal of cancer - 1 May 2003
Zhu Hong-Xia, Zhou Cui-Qi, Zhang Guo, Zhou Xiao-Bo, Liu Shuang, Bai Jin-Feng, Quan Lan-Ping, Dong Zhi-Wei, Xu Ning-Zhi
Abstract excerpt
BACKGROUND & OBJECTIVE: Survivin was aberrantly expressed in most cancer tissues, suggesting that survivin plays an important role in carcinogenesis. This study was designed to investigate the function and mechanism of survivin mutants in tumor cells. METHODS: The site-mutant and truncated survivin mutants were transfected into HeLa cells and selected using G418. Cell apoptosis was analyzed using flow cytometry....
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