Article
Association of CYP2A6 gene deletion with cigarette smoking status in Japanese adults.
Journal of epidemiology - 1 May 2003
Ando Masahiko, Hamajima Nobuyuki, Ariyoshi Noritaka, Kamataki Tetsuya, Matsuo Keitaro, Ohno Yoshiyuki
Abstract excerpt
BACKGROUND: Genetic variation of CYP2A6 is shown to alter nicotine metabolism. This study was developed to investigate the genetic influence of the whole deletion-allele of CYP2A6 on active and passive smoking behavior. METHODS: Two hundred and forty Japanese adults, who visited Aichi Cancer Center as outpatients, were genotyped for the wild-type (CYP2A6*1A, CYP2A6*1B) and the whole deletion-type (CYP2A6*4C)...
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